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During the opening lecture at the International Conference on Advanced Technologies & Treatments for Diabetes, Melanie Davies, CBE, MB, ChB, MD, FRCP, FRCGP, professor of diabetes medicine at the University of Leicester and an honorary consultant diabetologist at the University Hospitals of Leicester NHS Trust, reviewed how GLP-1 receptor agonists such as semaglutide (Ozempic/Wegovy, Novo Nordisk) have changed the way providers approach the treatment of type 2 diabetes and obesity and discussed some of the medications that combine GLP-1 with other molecules

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(2) Sirt1 and Sirt3 preferentially remove the acetyl group over the butyryl group, whereas Sirt2 and Sirt6 preferentially remove the butyryl group over the acetyl group (acyl group-selectivity between acetyl versus butyryl group)