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Tirzepatide (marketed in September 2022) was excluded due to insufficient data, and semaglutide was the latest drug of interest to be marketed (December 2017)

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In studies using human gingival and periodontal stem cells [4, 45], Epitalon enhanced the expression of: Nestin (neural progenitor marker) GAP43 (axon growth) -Tubulin III and Doublecortin (neuronal differentiation and migration) Together, these shifts suggest Epitalon may prime stem cells toward neuronal lineage, hinting at applications in regenerative neurology or brain injury recovery models

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