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Insulin syringe injections are typically quick (just a few seconds) and almost painless due to the thin needle

Annu Rev Biochem 71:537592 Botta D, White CC, Vliet-Gregg P, Mohar I, Shi S, McGrath MB, McConnachie LA, Kavanagh TJ (2008) Modulating GSH synthesis using glutamate cysteine ligase transgenic and gene-targeted mice

Studies using techniques like microneedling show dramatically enhanced penetration - up to ten-fold increases - but even standard topical application delivers meaningful amounts to the target tissue

In one study, only 8% of women with recurrent vaginal thrush had flare-ups during six months of fluconazole (Diflucan) treatment, compared with 64% of those on a placebo

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In some embodiments, the otic formulation or composition comprises between about 0.10% to about 15% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof