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[6] It complements MOTS-c as the second well-studied peptide from mitochondrial DNA

T.VinarskyV.et al (2002)

& Moriya, M

Given that trypsin possesses distinct biochemical properties, structural features, and physiological context compared to TMPRSS2, it may not fully replicate the spatiotemporal regulation required for TMPRSS2-dependent spike proteolytic activation